A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).
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Marina Corral Spence
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J.R. is an inventor on issued and pending patents on new mechanisms and technologies for proteinuric kidney diseases. He stands to gain royalties from the commercialization of these technologies.
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Reiser, J. Akt2 relaxes podocytes in chronic kidney disease. Nat Med 19, 1212–1213 (2013). https://doi.org/10.1038/nm.3357
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DOI: https://doi.org/10.1038/nm.3357
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