Skip to main content

Advertisement

Log in

Immunotherapy at Large: Balancing tumor immunity and inflammatory pathology

  • Between Bedside and Bench
  • Published:

From Nature Medicine

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: The need to balance the antitumor activity and toxicity of single and combinatorial immunotherapies.

Marina Corral Spence

References

  1. Elion, G.B. Cancer Res. 45, 2943–2950 (1985).

    CAS  PubMed  Google Scholar 

  2. Hamid, O. et al. N. Engl. J. Med. 369, 134–144 (2013).

    Article  CAS  Google Scholar 

  3. Wolchok, J.D. et al. N. Engl. J. Med. 369, 122–133 (2013).

    Article  CAS  Google Scholar 

  4. Mellman, I., Coukos, G. & Dranoff, G. Nature 480, 480–489 (2011).

    Article  CAS  Google Scholar 

  5. Sharma, P., Wagner, K., Wolchok, J.D. & Allison, J.P. Nat. Rev. Cancer 11, 805–812 (2011).

    Article  CAS  Google Scholar 

  6. Keir, M.E., Butte, M.J., Freeman, G.J. & Sharpe, A.H. Annu. Rev. Immunol. 26, 677–704 (2008).

    Article  CAS  Google Scholar 

  7. Topalian, S.L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).

    Article  CAS  Google Scholar 

  8. Dranoff, G. Nat. Rev. Immunol. 12, 61–66 (2011).

    Article  Google Scholar 

  9. Vanneman, M. & Dranoff, G. Nat. Rev. Cancer 12, 237–251 (2012).

    Article  CAS  Google Scholar 

  10. Brahmer, J.R. et al. N. Engl. J. Med. 366, 2455–2465 (2012).

    Article  CAS  Google Scholar 

  11. Brahmer, J.R. & Pardoll, D.M. Cancer Immunol. Res. 1, 85–91 (2013).

    Article  CAS  Google Scholar 

  12. Ploegh, H.L. Cancer Immunol. Res. 1, 5–10 (2013).

    Article  CAS  Google Scholar 

  13. Nowarski, R., Gagliani, N., Huber, S. & Flavell, R.A. Cancer Immunol. Res. 1, 77–84 (2013).

    Article  CAS  Google Scholar 

  14. Hodi, F.S. et al. J. Clin. Oncol. 31, abstr. CRA9007 (2013).

  15. Jinushi, M. et al. J. Clin. Invest. 117, 1902–1913 (2007).

    Article  CAS  Google Scholar 

  16. Schreiber, R.D., Old, L.J. & Smyth, M.J. Science 331, 1565–1570 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Glenn Dranoff.

Ethics declarations

Competing interests

G.D. receives research support from Bristol-Myers Squibb and from Novartis, where he is also a consultant. He has been a guest lecturer at Merck and Genentech.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dranoff, G. Immunotherapy at Large: Balancing tumor immunity and inflammatory pathology. Nat Med 19, 1100–1101 (2013). https://doi.org/10.1038/nm.3335

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3335

  • Springer Nature America, Inc.

This article is cited by

Navigation