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LRH-1: orphaned, adopted and needed for pregnancy

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A new study shows that the orphan nuclear receptor liver receptor homolog 1 (LRH-1) wires the postovulatory rise in progesterone production to progesterone-dependent preparation of the endometrium for pregnancy, a process termed decidualization. Lack of Lrh-1 activity in either the ovary or uterus has catastrophic consequences for reproduction in mice (pages 1061–1066).

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Figure 1: LRH-1 integrates progesterone production in the ovary and actions in the uterus.

Marina Corral Spence

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Authors and Affiliations

  1. Jan J. Brosens, Andrew M. Blanks and Emma S. Lucas are in the Biomedical Research Unit in Reproductive Health, Warwick Medical School, University Hospital Coventry & Warwickshire, Coventry, UK.,

    Jan J Brosens, Andrew M Blanks & Emma S Lucas

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  1. Jan J Brosens
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  2. Andrew M Blanks
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  3. Emma S Lucas
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Correspondence to Jan J Brosens.

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Brosens, J., Blanks, A. & Lucas, E. LRH-1: orphaned, adopted and needed for pregnancy. Nat Med 19, 968–969 (2013). https://doi.org/10.1038/nm.3271

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