Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).
References
Berenbaum, F. Osteoarthritis Cartilage 21, 16–21 (2013).
Felson, D.T. Osteoarthritis Cartilage 21, 10–15 (2013).
Goldring, M.B. & Goldring, S.R. Ann. NY Acad. Sci. 1192, 230–237 (2010).
Zhen, G. et al. Nat. Med. 19, 704–712 (2013).
Janssens, K. et al. J. Med. Genet. 43, 1–11 (2006).
Felson, D.T. et al. Ann. Intern. Med. 134, 541–549 (2001).
Tang, Y. et al. Nat. Med. 15, 757–765 (2009).
Burr, D.B. & Gallant, M.A. Nat. Rev. Rheumatol. 8, 665–673 (2012).
Whyte, M.P. et al. J. Bone Miner. Res. 26, 920–933 (2011).
Serra, R. et al. J. Cell Biol. 139, 541–552 (1997).
Yang, X. et al. J. Cell Biol. 153, 35–46 (2001).
Blaney Davidson, E.N., van der Kraan, P.M. & van den Berg, W.B. Osteoarthritis Cartilage 15, 597–604 (2007).
van der Kraan, P.M. et al. Cell Tissue Res. 347, 257–265 (2012).
van Beuningen, H.M. et al. Lab. Invest. 71, 279–290 (1994).
Scharstuhl, A. et al. Arthritis Rheum. 48, 3442–3451 (2003).
Pitsillides, A.A. & Beier, F. Nat. Rev. Rheumatol. 7, 654–663 (2011).
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Bush, J., Beier, F. TGF-β and osteoarthritis—the good and the bad. Nat Med 19, 667–669 (2013). https://doi.org/10.1038/nm.3228
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DOI: https://doi.org/10.1038/nm.3228
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