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Coagulation factor defends adenovirus from immune attack

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Adenovirus type 5 (Ad5) has been intensively studied as a viral vector for gene therapy, and understanding host–Ad5 interactions will be key to the safe and effective use of this vector. A recent study in mice provides new insights in this area by showing that Ad5 enlists a host coagulation factor to overcome complement-mediated blockade and infect the liver (pages 452–457).

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Figure 1: Adenovirus liver tropism is regulated by interactions with FX.

Katie Vicari

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Authors and Affiliations

  1. Glen R. Nemerow is in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Glen R Nemerow

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  1. Glen R Nemerow
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Correspondence to Glen R Nemerow.

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Nemerow, G. Coagulation factor defends adenovirus from immune attack. Nat Med 19, 406–407 (2013). https://doi.org/10.1038/nm.3149

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