Production of the amyloid-β peptide in Alzheimer's disease by the γ-secretase complex can be regulated by certain G protein–coupled receptors. This regulation seems to be mediated by β-arrestin-2, whose expression was found to be elevated in Alzheimer's disease brains (pages 43–49).
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Marina Corral
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Wolfe, M. Alzheimer's γ-secretase under arrestin. Nat Med 19, 22–24 (2013). https://doi.org/10.1038/nm.3053
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DOI: https://doi.org/10.1038/nm.3053
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