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Metabolic jet lag when the fat clock is out of sync

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There is a growing appreciation of the importance of circadian regulation in energy homeostasis, and the dysregulation of the circadian clock has been associated with obesity and metabolic abnormalities. A new study shows that adipocyte-specific deletion of a core circadian clock gene, Arntl (Bmal1), in mice shifts the timing of their feeding behavior, resulting in obesity (pages 1768–1777).

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Figure 1: Effects of Arntl knockout in different cell types in mice.

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Acknowledgements

The authors are supported by the US National Institutes of Health (grants R01-DK55758 and P01DK088761-01 to P.E.S.). I.W.A. was also supported by a fellowship from the Throne-Holst Foundation and the Swedish Research Council (2006-3931) and by a VINNMER fellowship from the VINNOVA Foundation.

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Authors and Affiliations

  1. Department of Internal Medicine, and Philipp E. Scherer is in the Department of Cell Biology, Philipp E. Scherer and Ingrid Wernstedt Asterholm are at the Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.,

    Ingrid Wernstedt Asterholm & Philipp E Scherer

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  1. Ingrid Wernstedt Asterholm
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  2. Philipp E Scherer
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Correspondence to Philipp E Scherer.

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The authors declare no competing financial interests.

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Asterholm, I., Scherer, P. Metabolic jet lag when the fat clock is out of sync. Nat Med 18, 1738–1740 (2012). https://doi.org/10.1038/nm.3010

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