Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained unclear. A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651–1657).
This is a preview of subscription content, log in via an institution to check access.
References
Zarbock, A., Ley, K., McEver, R.P. & Hidalgo, A. Blood 118, 6743–6751 (2011).
Ding, L., Saunders, T.L., Enikolopov, G. & Morrison, S.J. Nature 481, 457–462 (2012).
Méndez-Ferrer, S. et al. Nature 466, 829–834 (2010).
Wilson, A. et al. Cell 135, 1118–1129 (2008).
Winkler, I.G. et al. Nat. Med. 18, 1651–1657 (2012).
Frenette, P.S., Mayadas, T.N., Rayburn, H., Hynes, R.O. & Wagner, D.D. Cell 84, 563–574 (1996).
Miyaoka, Y. et al. Biochem. J. 440, 33–41 (2011).
Yang, T. et al. J. Clin. Invest. 120, 2474–2485 (2010).
Blank, U. & Karlsson, S. Leukemia 25, 1379–1388 (2011).
Fortunel, N.O., Hatzfeld, A. & Hatzfeld, J.A. Blood 96, 2022–2036 (2000).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Declaration: M.A.S.M. holds patents on granulocyte colony–stimulating factor [AU: with which patent office?] and receives royalties from Amgen.
Rights and permissions
About this article
Cite this article
Moore, M. Waking up HSCs: a new role for E-selectin. Nat Med 18, 1613–1614 (2012). https://doi.org/10.1038/nm.2992
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.2992
- Springer Nature America, Inc.
This article is cited by
-
Leukemia circulation kinetics revealed through blood exchange method
Communications Biology (2024)
-
Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes
Communications Biology (2023)