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Heat from calcium cycling melts fat

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A new study in mice shows that sarcolipin, a small, regulatory protein of the intracellular calcium pump (SERCA) in skeletal muscle, is part of a nonshivering thermogenic mechanism for regulating both core body temperature and energy balance (pages 1575–1579).

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Figure 1: Nonshivering thermogenesis (NST) from muscle and brown adipose tissue (BAT).

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Authors and Affiliations

  1. Leslie P. Kozak is at the Institute of Animal Reproduction and Food Research of the Polish Academy of Science, Olsztyn, Poland.,

    Leslie P Kozak

  2. Martin E. Young is in the Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.,

    Martin E Young

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  1. Leslie P Kozak
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  2. Martin E Young
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Correspondence to Leslie P Kozak.

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The authors declare no competing financial interests.

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Kozak, L., Young, M. Heat from calcium cycling melts fat. Nat Med 18, 1458–1459 (2012). https://doi.org/10.1038/nm.2956

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