Skip to main content

Advertisement

SpringerLink
Log in

Protect thee from the sins of thy fathers?

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Hepatic fibrosis results from chronic liver injury due to viral infection, metabolic diseases, toxins such as alcohol, or immune attack. Now, a heritable epigenetic determinant of fibrosis has been uncovered, providing evidence that sperm from male rats with liver injury confers reduced fibrosis in their male offspring (pages 1369– 1377).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Paternal epigenetic suppression of hepatic fibrosis in male progeny via a transmissible factor.

References

  1. Hernandez-Gea, V. & Friedman, S.L. Annu. Rev. Pathol. 6, 425–456 (2011).

    Article  CAS  Google Scholar 

  2. Weber, S., Gressner, O.A., Hall, R., Grunhage, F. & Lammert, F. Clin. Liver Dis. 12, 747–757 (2008).

    Article  Google Scholar 

  3. Zeybel, M. et al. Nat. Med. 18, 1369–1377 (2012).

    Article  CAS  Google Scholar 

  4. Friedman, S.L. Nat. Rev. Gastroenterol. Hepatol. 7, 425–436 (2010).

    Article  Google Scholar 

  5. Relton, C.L. et al. PLoS One 7, e31821 (2012).

    Article  CAS  Google Scholar 

  6. Dietz, D.M. et al. Biol. Psychiatry 70, 408–414 (2011).

    Article  Google Scholar 

  7. Dietz, D.M. & Nestler, E.J. Neuropsychopharmacology 37, 311–312 (2012).

    Article  Google Scholar 

  8. Knezovich, J.G. & Ramsay, M. Front. Genet. 3, 10 (2012).

    Article  CAS  Google Scholar 

  9. Jenkins, T.G. & Carrell, D.T. Reproduction 143, 727–734 (2012).

    Article  CAS  Google Scholar 

  10. Cuzin, F. & Rassoulzadegan, M. Essays Biochem. 48, 101–106 (2010).

    Article  CAS  Google Scholar 

  11. Haafiz, A.B. Expert Rev. Gastroenterol. Hepatol. 4, 335–343 (2010).

    Article  Google Scholar 

  12. Stickel, F. & Hampe, J. Gut 61, 150–159 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Scott L. Friedman is in the Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.,

    Scott L Friedman

Authors
  1. Scott L Friedman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Scott L Friedman.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Friedman, S. Protect thee from the sins of thy fathers?. Nat Med 18, 1331–1332 (2012). https://doi.org/10.1038/nm.2936

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2936

  • Springer Nature America, Inc.

Search

Navigation