T cells responding to tumor cells and chronic viral pathogens are ineffective because their function is suppressed by inhibitory receptors such as Tim-3. New work identifies the first component of the Tim-3 inhibitory signaling pathway in T cells (pages 1394–1400).
References
Wherry, E.J. Nat. Immunol. 12, 492–499 (2011).
Rangachari, M. et al. Nat. Med. 18, 1394–1400 (2012)
Monney, L. et al. Nature 415, 536–541 (2002).
Zhu, C. et al. Nat. Immunol. 6, 1245–1252 (2005).
Sabatos, C.A. et al. Nat. Immunol. 4, 1102–1110 (2003).
Sánchez-Fueyo, A. et al. Nat. Immunol. 4, 1093–1101 (2003).
Jones, R.B. et al. J. Exp. Med. 205, 2763–2779 (2008).
Golden-Mason, L. et al. J. Virol. 83, 9122–9130 (2009).
Fourcade, J. et al. J. Exp. Med. 207, 2175–2186 (2010).
Thress, K., Henzel, W., Shillinglaw, W. & Kornbluth, S. EMBO J. 17, 6135–6143 (1998).
Topalian, S.L. et al. N. Engl. J. Med. 366, 2443–2454 (2012).
Brahmer, J.R. et al. N. Engl. J. Med. 366, 2455–2465 (2012).
Quigley, M. et al. Nat. Med. 16, 1147–1151 (2010).
Parry, R.V. et al. Mol. Cell. Biol. 25, 9543–9553 (2005).
Patsoukis, N. et al. Sci. Signal. 5, ra46 (2012).
Blackburn, S.D. et al. Nat. Immunol. 10, 29–37 (2009).
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Haining, W. Thinking inside the box: how T cell inhibitory receptors signal. Nat Med 18, 1338–1339 (2012). https://doi.org/10.1038/nm.2921
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DOI: https://doi.org/10.1038/nm.2921
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