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Cutting SRC-1 down to size in endometriosis

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Endometriosis occurs when estrogen-sensitive endometrial cells that are shed to distal sites manage to attach and survive in a foreign, inflammatory environment. A new study reports a unique interaction between a cleaved form of steroid receptor coactivator 1 (SRC-1) and caspase 8 that blocks apoptosis in endometriotic cells, allowing them to survive (pages 1102–1111).

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Figure 1: SRC-1 in the etiology of endometriosis.

Katie Vicari

References

  1. Nnoaham, K.E. et al. Fertil. Steril. 96, 366–373 (2011).

    Article  Google Scholar 

  2. Bulun, S.E. N. Engl. J. Med. 360, 268–279 (2009).

    Article  CAS  Google Scholar 

  3. Sampson, J.A. Am. J. Obstet. Gynecol. 14, 422–469 (1927).

    Article  Google Scholar 

  4. Giudice, L.C. N. Engl. J. Med. 362, 2389–2398 (2010).

    Article  CAS  Google Scholar 

  5. Nasu, K., Yuge, A., Tsuno, A., Nishida, M. & Narahara, H. Histol. Histopathol. 24, 1181–1192 (2009).

    CAS  Google Scholar 

  6. Han, S.J. et al. Nat. Med. 18, 1102–1111 (2012).

    Article  CAS  Google Scholar 

  7. Gaide Chevronnay, H.P. et al. Biochim. Biophys. Acta 1824, 146–156 (2012).

    Article  CAS  Google Scholar 

  8. Stilley, J.A., Woods-Marshall, R., Sutovsky, M., Sutovsky, P. & Sharpe-Timms, K.L. Biol. Reprod. 80, 649–656 (2009).

    Article  CAS  Google Scholar 

  9. Hansen, K.D. et al. Nat. Genet. 43, 768–775 (2011).

    Article  CAS  Google Scholar 

  10. Braundmeier, A.G. & Fazleabas, A.T. Mol. Hum. Reprod. 15, 577–586 (2009).

    Article  CAS  Google Scholar 

  11. McBryan, J. et al. Cancer Res. 72, 548–559 (2012).

    Article  CAS  Google Scholar 

  12. York, B. & O'Malley, B.W. J. Biol. Chem. 285, 38743–38750 (2010).

    Article  CAS  Google Scholar 

  13. Islimye, M. et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 159, 184–189 (2011).

    Article  CAS  Google Scholar 

  14. Giraudo, E., Inoue, M. & Hanahan, D. J. Clin. Invest. 114, 623–633 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Matthew T. Dyson and Serdar E. Bulun are in the Department of Obstetrics and Gynecology at Feinberg School of Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA.,

    Matthew T Dyson & Serdar E Bulun

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  1. Matthew T Dyson
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  2. Serdar E Bulun
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Correspondence to Serdar E Bulun.

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The authors declare no competing financial interests.

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Dyson, M., Bulun, S. Cutting SRC-1 down to size in endometriosis. Nat Med 18, 1016–1018 (2012). https://doi.org/10.1038/nm.2855

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