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Primed for inflammation: enthesis-resident T cells

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The enthesis is the region at the junction between tendon and bone and has been suggested to be a key target in spondyloarthritic diseases. This zone is now shown to contain a unique population of resident T cells, which, when activated by the cytokine interleukin-23 (IL-23), can promote pathogenesis that is characteristic of spondyloarthritis (pages 1069–1076).

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Figure 1: IL-23 and entheseal-resident T cells in the pathogenesis of spondyloarthritis.

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Author notes

  1. Iain B. McInnes is in the College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK.

Authors and Affiliations

  1. Rik J. Lories is in the Department of Development and Regeneration, KU Leuven, Leuven, Belgium.,

    Rik J Lories & Iain B McInnes

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  1. Rik J Lories
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  2. Iain B McInnes
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Correspondence to Rik J Lories or Iain B McInnes.

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Competing interests

I.B.M. received honoraria from Janssen and Novartis.

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Lories, R., McInnes, I. Primed for inflammation: enthesis-resident T cells. Nat Med 18, 1018–1019 (2012). https://doi.org/10.1038/nm.2854

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