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Melanoma exosomes: messengers of metastasis

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A new study shows that melanoma-derived exosomes contribute to metastatic invasion by carrying messenger proteins that direct bone marrow–derived cells toward a prometastatic phenotype. This leads to the promotion of proangiogenic events and modification of the extracellular matrix at premetastatic sites (pages 883–891).

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Figure 1: Melanoma-derived exosomes are messengers for angiogenesis and metastatic invasion.

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Authors and Affiliations

  1. Rajasekharan Somasundaram and Meenhard Herlyn are in the Tumor Microenvironment and Metastasis Program, Melanoma Research Center, The Wistar Institute, Philadelphia, Pennsylvania, USA.,

    Rajasekharan Somasundaram & Meenhard Herlyn

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  1. Rajasekharan Somasundaram
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  2. Meenhard Herlyn
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Correspondence to Meenhard Herlyn.

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The authors declare no competing financial interests.

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Somasundaram, R., Herlyn, M. Melanoma exosomes: messengers of metastasis. Nat Med 18, 853–854 (2012). https://doi.org/10.1038/nm.2775

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