A newly identified role for SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) in the regulation of histone ubiquitination uncovers a broad tumor suppressor activity that helps to maintain genomic stability in mice. A recent study suggests a new mechanism underlying the role of ubiquitination in cancer (pages 227–234).
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Katie Vicari
References
Hershko, A. & Ciechanover, A. Annu. Rev. Biochem. 67, 425–479 (1998).
Hoeller, D. & Dikic, I. Nature 458, 438–444 (2009).
Kavsak, P. et al. Mol. Cell 6, 1365–1375 (2000).
Narimatsu, M. et al. Cell 137, 295–307 (2009).
Fukuchi, M. et al. Cancer Res. 62, 7162–7165 (2002).
Jin, C. et al. Cancer Res. 69, 735–740 (2009).
Blank, M. et al. Nat. Med. 18, 227–234 (2012).
Wang, H. et al. Nature 431, 873–878 (2004).
Simon, J.A. & Kingston, R.E. Nat. Rev. Mol. Cell Biol. 10, 697–708 (2009).
Zhu, B. et al. Mol. Cell 20, 601–611 (2005).
Fierz, B. et al. Nat. Chem. Biol. 7, 113–119 (2011).
Nakamura, K. et al. Mol. Cell 41, 515–528 (2011).
Wilson, B.G. & Roberts, C.W. Nat. Rev. Cancer 11, 481–492 (2011).
Rodríguez-Paredes, M. & Esteller, M. Nat. Med. 17, 330–339 (2011).
Morin, R.D. et al. Nature 476, 298–303 (2011).
Pasqualucci, L. et al. Nat. Genet. 43, 830–837 (2011).
Zhu, Q. et al. Nature 477, 179–184 (2011).
Ginjala, V. et al. Mol. Cell. Biol. 31, 1972–1982 (2011).
Li, X.S., Trojer, P., Matsumura, T., Treisman, J.E. & Tanese, N. Mol. Cell. Biol. 30, 1673–1688 (2010).
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Wang, X., Roberts, C. Cancer-fighting Smurf. Nat Med 18, 204–205 (2012). https://doi.org/10.1038/nm.2655
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DOI: https://doi.org/10.1038/nm.2655
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