Skip to main content

Advertisement

SpringerLink
Log in

A gut triumvirate rules homeostasis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

IgA regulates intestinal homeostasis by maintaining appropriate communities of bacteria within the gut. A new study shows that intestinal bacteria regulate metabolism via IgA (pages 1585–1593).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Intestinal bacteria regulate metabolism and immunity through an IgA-dependent mechanism.

Marina Corral

References

  1. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Cell 118, 229–241 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Cerutti, A., Chen, K. & Chorny, A. Annu. Rev. Immunol. 29, 273–293 (2011).

    Article  CAS  PubMed  Google Scholar 

  3. Hapfelmeier, S. et al. Science 328, 1705–1709 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. Benckert, J. et al. J. Clin. Invest. 121, 1946–1955 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Peterson, D.A., McNulty, N.P., Guruge, J.L. & Gordon, J.I. Cell Host Microbe 2, 328–339 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Fagarasan, S. et al. Science 298, 1424–1427 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. Wei, M. et al. Nat. Immunol. 12, 264–270 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Shulzhenko, N. et al. Nat. Med. 17, 1585–1593 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. He, B. et al. Immunity 26, 812–826 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Macpherson, A.J. & Uhr, T. Science 303, 1662–1665 (2004).

    Article  CAS  PubMed  Google Scholar 

  11. Malamut, G. et al. Am. J. Gastroenterol. 105, 2262–2275 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. Vijay-Kumar, M. et al. Science 328, 228–231 (2010).

    Article  CAS  PubMed  Google Scholar 

  13. Uematsu, S. et al. Nat. Immunol. 9, 769–776 (2008).

    Article  CAS  PubMed  Google Scholar 

  14. Round, J.L. & Mazmanian, S.K. Nat. Rev. Immunol. 9, 313–323 (2009).

    Article  CAS  PubMed  Google Scholar 

  15. Xu, W. et al. Nat. Immunol. 10, 1008–1017 (2009).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alejo Chorny and Andrea Cerutti are at The Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA and the Institut Municipal d'Investicació Mèdica-Hospital del Mar, Barcelona Biomedical Research Park, Barcelona, Spain,

    Alejo Chorny & Andrea Cerutti

  2. Andrea Cerutti is also at the Catalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Barcelona, Spain.,

    Andrea Cerutti

Authors
  1. Alejo Chorny
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Cerutti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrea Cerutti.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chorny, A., Cerutti, A. A gut triumvirate rules homeostasis. Nat Med 17, 1549–1550 (2011). https://doi.org/10.1038/nm.2592

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2592

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation