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SGK1: a fine balancing act for human pregnancy

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A new study suggests that regulation of the serum- and glucocorticoid-regulated kinase (SGK1) is important for ensuring uterine receptivity and maintenance of pregnancy (pages 1509–1513). Additional work will be required to determine whether SGK1 could be potentially targeted to treat infertility and prevent miscarriage and whether it can be used as a biomarker.

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Figure 1: Balancing SGK1 expression to regulate pregnancy.

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Authors and Affiliations

  1. Susan J. Fisher and Linda C. Giudice are in the Department of Obstetrics, Gynecology and Reproductive Sciences, University of California–San Francisco, San Francisco, USA and the Center for Reproductive Sciences, University of California–San Francisco, San Francisco, USA.,

    Susan J Fisher & Linda C Giudice

  2. Susan J. Fisher is also in the Department of Anatomy, the Division of Maternal Fetal Medicine, University of California–San Francisco, San Francisco, USA, University of California–San Francisco, San Francisco, USA, The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research at the University of California–San Francisco, San Francisco, USA, the Human Embryonic Stem Cell Program, University of California–San Francisco, San Francisco, USA and the Sandler-Moore Mass Spectrometry Core Facility, University of California–San Francisco, San Francisco, USA.,

    Susan J Fisher

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  1. Susan J Fisher
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  2. Linda C Giudice
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Correspondence to Susan J Fisher or Linda C Giudice.

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The authors declare no competing financial interests.

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Fisher, S., Giudice, L. SGK1: a fine balancing act for human pregnancy. Nat Med 17, 1348–1349 (2011). https://doi.org/10.1038/nm.2549

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