Skip to main content
SpringerLink
Log in

A ribosomal tactic to halt cancer

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The ribosomal protein RPL11 can block cell growth by boosting function of the tumor suppressor p53 in response to ribosomal stress, but the connection of this role with cancer has been obscure. New findings show that the nucleolar protein PICT1 can sequester RPL11, impairing p53 activation and favoring tumor growth (pages 944–951).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The imbalance of nucleolar PICT1 abundance modifies the oncogenic potential by controlling the RPL11-MDM2-p53 pathway.

Marina Corral

References

  1. Warner, J.R. & McIntosh, K.B. Mol. Cell 34, 3–11 (2009).

    Article  CAS  Google Scholar 

  2. Zhang, Y. & Lu, H. Cancer Cell 16, 369–377 (2009).

    Article  CAS  Google Scholar 

  3. Lohrum, M.A. et al. Cancer Cell 3, 577–587 (2003).

    Article  CAS  Google Scholar 

  4. Zhang, Y. et al. Mol. Cell. Biol. 23, 8902–8912 (2003).

    Article  CAS  Google Scholar 

  5. Dai, M.S. et al. Mol. Cell. Biol. 24, 7654–7668 (2004).

    Article  CAS  Google Scholar 

  6. Dai, M.S. & Lu, H. J. Biol. Chem. 279, 44475–44482 (2004).

    Article  CAS  Google Scholar 

  7. Sasaki, M. et al. Nat. Med. 17, 944–951 (2011).

    Article  CAS  Google Scholar 

  8. Barlow, J.L. et al. Nat. Med. 16, 59–66 (2010).

    Article  CAS  Google Scholar 

  9. Macias, E. et al. Cancer Cell 18, 231–243 (2010).

    Article  CAS  Google Scholar 

  10. Okahara, F. et al. Mol. Biol. Cell 17, 4888–4895 (2006).

    Article  CAS  Google Scholar 

  11. Smith, J.S. et al. Genomics 64, 44–50 (2000).

    Article  CAS  Google Scholar 

  12. Cairncross, J.G. et al. J. Natl. Cancer Inst. 90, 1473–1479 (1998).

    Article  CAS  Google Scholar 

  13. Dai, M.S. et al. Mol. Cell. Biol. 28, 4365–4376 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hua Lu is in the Department of Biochemistry & Molecular Biology, Indiana University School of Medicine–Simon Cancer Center, Indianapolis, Indiana, USA.,

    Hua Lu

Authors
  1. Hua Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hua Lu.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, H. A ribosomal tactic to halt cancer. Nat Med 17, 930–931 (2011). https://doi.org/10.1038/nm.2434

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.2434

  • Springer Nature America, Inc.

Search

Navigation