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A step toward slaying the hydra of second cancers

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Second cancers are a substantial clinical problem in survivorship. A genome-wide association study (GWAS) in survivors of Hodgkin's lymphoma treated with radiotherapy now identifies a region of susceptibility on chromosome 6q21 (pages 941–943), paving the way for further investigations of the complex interplay between genetic susceptibility and environmental exposures involved in the development of second cancers.

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Figure 1: Theoretical contributions of first primary cancer treatments, genetic susceptibility, and environmental and lifestyle factors to risk of second cancers by age.

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Authors and Affiliations

  1. Lindsay M. Morton & Stephen J. Chanock are in the Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA.,

    Lindsay M Morton & Stephen J Chanock

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  1. Lindsay M Morton
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  2. Stephen J Chanock
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Correspondence to Stephen J Chanock.

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Morton, L., Chanock, S. A step toward slaying the hydra of second cancers. Nat Med 17, 924–925 (2011). https://doi.org/10.1038/nm.2428

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