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Channels of communication in the ovary

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In mammals, unfertilized eggs and corpora lutea originate from Graafian follicles in the ovary. Two recent reports support the view that to produce Graafian follicles, oocytes and surrounding granulosa cells must communicate with each other. However, there is evidence to suggest that oocyte development can take place in the absence of granulosa cells.

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Figure 1: Stages of follicular growth in mammals.

References

  1. Pedersen, T. in Oogenesis (eds, Biggers, J.D. & Schuetz, A.W.) 361–376 (University Park Press, Baltimore, 1972).

    Google Scholar 

  2. Matzuk, M.M., Burns, K.H., Viveiros, M.M. & Eppig, J.J. Science 296, 2178–2180 (2002).

    Article  CAS  Google Scholar 

  3. Simon, A.M., Goodenough, D.A., Li, B.Y. & Paul, D.L. Nature 385, 525–529 (1997).

    Article  CAS  Google Scholar 

  4. Ackert, C.L., Gittens, J.E., O'Brien, M.J., Eppig, J.J. & Kidder, G.M. Dev. Biol. 233, 258–270 (2001).

    Article  CAS  Google Scholar 

  5. Dong, J., Albertini, D.F., Nishimori, K., Kumar, T.R., Lu, N. & Matzuk, M. Nature 383, 531–535 (1996).

    Article  CAS  Google Scholar 

  6. Carabatsos, M.J., Elvin, J., Matzuk, M.M. & Albertini, D.F. Dev. Biol. 204, 373–384 (1998).

    Article  CAS  Google Scholar 

  7. Eppig, J.J., Wigglesworth, K. & Pendola, F.L. Proc. Natl Acad. Sci. USA 99, 2890–2894 (2002).

    Article  CAS  Google Scholar 

  8. Klinger, F.G. & De Felici, M. Dev. Biol. 244, 85–95 (2002).

    Article  CAS  Google Scholar 

  9. Upadhyay, S. & Zamboni, L. Proc. Natl Acad. Sci. USA 79, 6584–6588 (1982).

    Article  CAS  Google Scholar 

  10. Zamboni, L. & Upadhyay, S. J. Expl. Zool. 228, 173–193 (1983).

    Article  CAS  Google Scholar 

  11. Baker, T.G. in Reproduction in mammals: 1 Germ cells and fertilization (eds Austin, C.R. & Short, R.V.) 17–45 (Cambridge University Press, Cambridge, 1982).

    Google Scholar 

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Wassarman, P. Channels of communication in the ovary. Nat Med 8 (Suppl 10), S7–S9 (2002). https://doi.org/10.1038/nm-fertilityS7

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  • DOI: https://doi.org/10.1038/nm-fertilityS7

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