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Competition for cytokines: Treg cells take all

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Thymus-derived regulatory T cells are thought to suppress target cells by either a cell contact–dependent mechanism or the production of inhibitory cytokines. A new study suggests a third strategy of apoptosis induced by the consumption of interleukin 2 and other T cell growth factors by regulatory T cells.

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Figure 1: Mechanisms of Treg cell supression.

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Authors and Affiliations

  1. Alexander Scheffold is with Deutsches Rheumaforschungszentrum Berlin, 10115 Berlin, Germany.,

    Alexander Scheffold

  2. Kenneth M. Murphy is in the Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA. kmurphy@wustl.edu,

    Kenneth M Murphy

  3. Thomas Höfer is with the German Cancer Research Center, Bioquant-Zentrum, BQ 0025, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany.,

    Thomas Höfer

Authors
  1. Alexander Scheffold
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  2. Kenneth M Murphy
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  3. Thomas Höfer
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Scheffold, A., Murphy, K. & Höfer, T. Competition for cytokines: Treg cells take all. Nat Immunol 8, 1285–1287 (2007). https://doi.org/10.1038/ni1207-1285

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