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The final cut: how ERAP1 trims MHC ligands to size

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Proteolytic cleavage generates the peptide repertoire displayed by MHC class I. Now, an interferon-γ–inducible aminopeptidase in the endoplasmic reticulum has been identified as the final player in this complex process.

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Figure 1: MHC class I processing pathway.

Bob Crimi

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Authors and Affiliations

  1. Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, Berlin, 13125, Germany

    Kirsten Falk & Olaf Rötzschke

Authors
  1. Kirsten Falk
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  2. Olaf Rötzschke
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Falk, K., Rötzschke, O. The final cut: how ERAP1 trims MHC ligands to size. Nat Immunol 3, 1121–1122 (2002). https://doi.org/10.1038/ni1202-1121

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