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The Immunological Genome Project: networks of gene expression in immune cells

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Abstract

The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells

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Figure 1: ImmGen consortium organization and project workflow.
Figure 2: Heat-map representation of 'problem transcripts' from replicate spleen CD4+ T cell samples (1 or 2) purified by each laboratory of the consortium (A–F) during the validation phase of the ImmGen profiling project.

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Acknowledgements

We thank eBiosciences, Affymetrix and Expression Analysis for participation and support. Supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R24 AI072073 to C.B.).

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Authors and Affiliations

  1. Department of Cancer Immunology and AIDS, and Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Kutlu Elpek, Veronika Lukacs-Kornek, Nora Mauermann & Shannon J Turley

  2. Department of Computer Science, Stanford University, Stanford, 94305, California, USA

    Daphne Koller

  3. Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Boston, 02115, Massachusetts, USA

    Francis S Kim

  4. Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, 02138, Massachusetts, USA

    Francis S Kim

  5. and Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Amy J Wagers, Amy J Wagers, Natasha Asinovski, Scott Davis, Marlys Fassett, Markus Feuerer, Daniel H D Gray, Sokol Haxhinasto, Jonathan A Hill, Gordon Hyatt, Catherine Laplace, Kristen Leatherbee, Diane Mathis & Christophe Benoist

  6. Department of Computer Science, Brown University, Providence, Rhode, 02912, Island, USA

    Radu Jianu & David H Laidlaw

  7. Division of Biological Sciences, University of California, San Diego, La Jolla, 92093, California, USA

    J Adam Best, Jamie Knell & Ananda W Goldrath

  8. Department of Microbiology & Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, 94143, California, USA

    Jessica Jarjoura, Joseph C Sun, Yanan Zhu & Lewis L Lanier

  9. Department of Biomechanical Engineering and Center for BioDynamics, Boston University, Boston, 02215, Massachusetts, USA

    Ayla Ergun, Zheng Li & James J Collins

  10. Division of Basic Science, Fox Chase Cancer Center, Philadelphia, 19111, Pennsylvania, USA

    Susan A Shinton & Richard R Hardy

  11. Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, Massachusetts, USA

    Randall Friedline, Katelyn Sylvia & Joonsoo Kang

  12. Principal investigator,

    Shannon J Turley, Daphne Koller, Diane Mathis, Christophe Benoist, David H Laidlaw, Ananda W Goldrath, Lewis L Lanier, James J Collins, Richard R Hardy & Joonsoo Kang

  13. Joslin Diabetes Center & Department of Medicine, Tracy S.P. Heng and Michio W. Painter are in the Section on Immunology and Immunogenetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA. immgen@joslin.harvard.edu,

    Tracy S P Heng & Michio W Painter

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  1. Tracy S P Heng
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  38. Joonsoo Kang
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The Immunological Genome Project Consortium

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Heng, T., Painter, M., The Immunological Genome Project Consortium. et al. The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol 9, 1091–1094 (2008). https://doi.org/10.1038/ni1008-1091

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