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Life amidst the contrivances

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The established dogma of 'horror autotoxicus' was overturned 50 years ago with the publication of a paper showing that autoimmune thyroiditis could be induced in animals. Noel Rose recounts the events that led to the establishment of autoimmunity as a cause of disease.

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References

  1. Ehrlich, P. Studies in Immunity (John Wiley & Sons, London, 1910; translated by Charles Bolduan).

    Google Scholar 

  2. Ehrlich stated: “Only when the internal regulatory contrivances are no longer intact can great dangers arise. In the explanation of many disease phenomena it will in the future be necessary to consider the possible failure of the internal regulations as well as the action of directly injurious exogenous or endogenous substances.” See ref. 1.

  3. Rose, N.R. Thyroid autoimmunity: a voyage of discovery. in: The Immunologic Revolution—Facts and Witnesses (eds. Szentivanyi, A. & Friedman, H.) 403–411 (CRC Press, Boca Raton, Florida, USA, 1993).

    Google Scholar 

  4. Rose, N.R. Studies of thyroid autoimmunity: their role in shaping modern immunology. in: Immunology: The Making of a Modern Science (eds. Gallagher, R.B., Gilder, J., Nossal, G.J.V. & Salvatore, G.) 231–236 (Academic Press, London, 1955).

    Google Scholar 

  5. Fairweather, D., Frisancho-Kiss, S. & Rose, N.R. Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis. Rev. Med. Virol. 15, 17–27 (2005).

    Article  CAS  Google Scholar 

  6. Witebsky, E. & Rose, N.R. Studies on organ specificity. IV. Production of rabbit thyroid antibodies in the rabbit. J. Immunol. 76, 408–416 (1956).

    CAS  PubMed  Google Scholar 

  7. Rose, N.R. & Witebsky, E. Studies on organ specificity. V. Changes in thyroid glands of rabbits following active immunization with rabbit thyroid extracts. Immunology 76, 417–427 (1956).

    CAS  Google Scholar 

  8. Roitt, I.M., Doniach, D., Campbell, P.N. & Vaughan Hudson, R. Autoantibodies in Hashimoto's disease (lymphadenoid goitre). Lancet 271, 820–821 (1956).

    Article  CAS  Google Scholar 

  9. Doniach, D. & Roitt, I.M. Autoimmunity in Hashimoto's disease and its implications. J. Clin. Endocrinol. Metab. 17, 1293–1304 (1957).

    Article  CAS  Google Scholar 

  10. Witebsky, E., Rose, N.R., Terplan, K., Paine, J.R. & Egan, R.W. Chronic thyroiditis and autoimmunization. J. Am. Med. Assoc. 164, 1439–1447 (1957).

    Article  CAS  Google Scholar 

  11. Rose, N.R. & Bona, C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today 14, 426–430 (1993).

    Article  CAS  Google Scholar 

  12. Miescher, P. & Fauconnet, M. L'absorption du facteur LE par des noyaux cellulaires isolés. Experientia (Basel) 10, 252–254 (1954).

    Google Scholar 

  13. Fellenberg von, R. & Rose, N.R. Antigenicity of insulin. Int. Arch. Allergy 33, 454–472 (1968).

    Article  Google Scholar 

  14. Vladutiu, A.O. & Rose, N.R. Autoimmune murine thyroiditis. Relation to histocompatibility (H-2) type. Science 174, 1137–1139 (1971).

    Article  CAS  Google Scholar 

  15. Bacon, L.D., Kite, J.H., Jr. & Rose, N.R. Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens. Science 186, 274–275 (1974).

    Article  CAS  Google Scholar 

  16. Welch, P., Rose, N.R. & Kite, J.H., Jr. Neonatal thymectomy increases spontaneous autoimmune thyroiditis. J. Immunol. 110, 575–577 (1973).

    CAS  PubMed  Google Scholar 

  17. Silverman, D.A. & Rose, N.R. Neonatal thymectomy increases the incidence of spontaneous and methylcholanthrene-enhanced thyroiditis in rats. Science 184, 162–163 (1974).

    Article  CAS  Google Scholar 

  18. Rose, N.R., Rasooly, L., Saboori, A.M. & Burek, C.L. Linking iodine with autoimmune thyroiditis. Environ. Health Perspect. 7 (Suppl 5.), 749–752 (1999).

    Google Scholar 

  19. Afanasyeva, M. & Rose, N.R. Viral infection and heart disease: autoimmune mechanisms. in Infection and Autoimmunity (eds. Shoenfeld, Y. & Rose, N.R.) 299–318 (Elsevier, Amsterdam, 2004).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and the Department of Molecular Microbiology and Immunology and is director of the Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins School of Medicine and Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, 21205, Maryland, USA

    Noel R Rose

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Rose, N. Life amidst the contrivances. Nat Immunol 7, 1009–1011 (2006). https://doi.org/10.1038/ni1006-1009

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  • DOI: https://doi.org/10.1038/ni1006-1009

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