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Hypermutation: give us a break

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Hypermutation and gene conversion appear to be distinct mechanisms that can explain somatic diversification of the antibody repertoire. Data in a recent Nature paper suggest unappreciated links between the two.

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Figure 1: One possible mechanism linking gene conversions and hypermutation in immunoglobulin V regions.

Bob Crimi

References

  1. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    Article  CAS  Google Scholar 

  2. Papavasiliou, F. N. & Schatz, D. G. Nature 408, 216–221 (2000).

    Article  CAS  Google Scholar 

  3. Bross, L. et al. Immunity 13, 589–597 (2000).

    Article  CAS  Google Scholar 

  4. Sale, J. E., Calandrini, D. M., Takata, M., Takeda, S. & Neuberger, M. S. Nature 412, 921–926 (2001).

    Article  CAS  Google Scholar 

  5. Maizels, N. Cell 83, 9–12 (1995).

    Article  CAS  Google Scholar 

  6. Weill, J. C. & Reynaud, C. A. Immunol. Today 17, 92–97 (1996).

    Article  CAS  Google Scholar 

  7. Holbeck, S. L. & Strathern, J. N. Genetics 147, 1017–1024 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Sonoda, E. et al. Mol. Cell Biol. 19, 5166–5169 (1999).

    Article  CAS  Google Scholar 

  9. Takata, M. et al. Mol. Cell Biol. 21, 2858–2866 (2001).

    Article  CAS  Google Scholar 

  10. Bemark, M. et al. J. Exp. Med. 192, 1509–1514 (2000).

    Article  CAS  Google Scholar 

  11. Pâques, F. & Haber, J. E. Microbiol. Mol. Biol. Rev. 63, 349–404 (1999).

    PubMed  PubMed Central  Google Scholar 

  12. Michel, B. Trends Biochem. Sci. 25, 173–178 (2000).

    Article  CAS  Google Scholar 

  13. Dalgaard, J. Z. & Klar, A. J. Trends Genet. 17, 153–157 (2001).

    Article  CAS  Google Scholar 

  14. Rada, C., Ehrenstein, M.R., Neuberger, M.S. & Milstein, C. Immunity 9, 135–141 (2000).

    Article  Google Scholar 

Download references

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  1. Brandeis University, Rosenstiel Center Mailstop 029, 415 South Street, Waltham, 02454-9110, MA, USA

    James E. Haber

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  1. James E. Haber
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Haber, J. Hypermutation: give us a break. Nat Immunol 2, 902–903 (2001). https://doi.org/10.1038/ni1001-902

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