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TH-17 differentiation: of mice and men

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A new subset of interleukin 17–producing CD4+ helper T cells with diverse functions has now been identified. New work by three groups substantially broadens the understanding of these cells in both mice and humans.

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Figure 1: T cell lineage commitment in humans versus mice.

Katie Ris-Vicari

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Authors and Affiliations

  1. Arian Laurence and John J. O'Shea are with the Molecular Immunology and Inflammation Branch of the National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. osheajo@mail.nih.gov,

    Arian Laurence & John J O'Shea

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  1. Arian Laurence
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  2. John J O'Shea
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Laurence, A., O'Shea, J. TH-17 differentiation: of mice and men. Nat Immunol 8, 903–905 (2007). https://doi.org/10.1038/ni0907-903

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