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Arresting autoimmunity by blocking β-arrestin 1

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The regulation of T cell survival and apoptosis contributes to the pathogenesis of autoimmune disease. A new study shows that the transcriptional regulator β-arrestin 1 enhances antiapoptotic Bcl-2 in T cells, which can heighten autoimmune disease.

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Figure 1: Regulation of transcription of Bcl2 by β-arrestin 1.

Katie Ris

References

  1. Shi, Y. et al. Nat. Immunol. 8, 817–824 (2007).

    Article  CAS  Google Scholar 

  2. Wekerle, H. Acta Neurol. (Napoli) 13, 197–204 (1991).

    CAS  Google Scholar 

  3. Begolka, W.S., Vanderlugt, C.L., Rahbe, S.M. & Miller, S.D. J. Immunol. 161, 4437–4446 (1998).

    CAS  PubMed  Google Scholar 

  4. Park, H. et al. Nat. Immunol. 6, 1133–1141 (2005).

    Article  CAS  Google Scholar 

  5. Chen, Y. et al. J. Clin. Invest. 116, 1317–1326 (2006).

    Article  CAS  Google Scholar 

  6. Langrish, C.L. et al. J. Exp. Med. 201, 233–240 (2005).

    Article  CAS  Google Scholar 

  7. Zhu, Y. et al. Proc. Natl. Acad. Sci. USA 101, 7681–7686 (2004).

    Article  CAS  Google Scholar 

  8. Okuda, Y., Okuda, M. & Bernard, C.C. J. Neuroimmunol. 131, 115–125 (2002).

    Article  CAS  Google Scholar 

  9. Ma, L. & Pei, G. J. Cell Sci. 120, 213–218 (2007).

    Article  CAS  Google Scholar 

  10. Kang, J. et al. Cell 123, 833–847 (2005).

    Article  CAS  Google Scholar 

  11. Nguyen, K. & Miller, B.C. J. Immunol. 168, 4440–4445 (2002).

    Article  CAS  Google Scholar 

  12. Vroon, A., Lombardi, M.S., Kavelaars, A. & Heijnen, C.J. J. Neuroimmunol. 137, 79–86 (2003).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Terra J. Frederick and Stephen D. Miller are in the Department of Microbiology-Immunology and the Interdepartmental Immunobiology Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. s-d-miller@northwestern.edu,

    Terra J Frederick & Stephen D Miller

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  1. Terra J Frederick
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  2. Stephen D Miller
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The authors declare no competing financial interests.

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Frederick, T., Miller, S. Arresting autoimmunity by blocking β-arrestin 1. Nat Immunol 8, 791–792 (2007). https://doi.org/10.1038/ni0807-791

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