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Epitope-specific regulation: the elephant in the bathtub

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Modern cellular and molecular studies have made great progress in characterizing the mechanisms that control immune responses. Now it is time to broaden the present views to accommodate evidence from epitope-specific and other immunoregulatory systems, which were well studied some years ago and are still highly relevant to contemporary work.

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Figure 1: Model T cell circuits that use idiotype recognition to control the epitope specificity of IgG antibody responses.

Katie Ris

Figure 2: Kinetics of epitope-specific suppression induction.

Katie Ris

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Authors and Affiliations

  1. Leonore A. Herzenberg is with the Department of Genetics, Stanford University, Stanford, California 94305, USA. leeherz@stanford.edu,

    Leonore A Herzenberg

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  1. Leonore A Herzenberg
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Herzenberg, L. Epitope-specific regulation: the elephant in the bathtub. Nat Immunol 8, 783–786 (2007). https://doi.org/10.1038/ni0807-783

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