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Rap1 redux

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Rap1 mediates 'inside-out' signaling from the T cell receptor to LFA-1. The discovery of RAPL, a Rap1-binding molecule, helps explain how Rap1 induces T cell adhesion.

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Figure 1: Dynamic regulation of T cell adhesion by TCR and chemokine-dependent signals.

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References

  1. Dustin, M.L. & Springer, T.A. Nature 341, 619–624 (1989).

    Article  CAS  Google Scholar 

  2. Springer, T.A. Cell 76, 301–314 (1994).

    Article  CAS  Google Scholar 

  3. Johnston, B. & Butcher, E.C. Sem. Immunol. 14, 83–92 (2002).

    Article  CAS  Google Scholar 

  4. Sebzda, E., Bracke, M., Tugal, T., Hogg, N. & Cantrell, D.A. Nat. Immunol. 3, 251–258 (2002).

    Article  CAS  Google Scholar 

  5. Katagiri, K., Hattori, M., Minato, N. & Kinashi, T. Mol. Cell. Biol. 22, 1001–1015 (2002).

    Article  CAS  Google Scholar 

  6. Katagiri, K., Maeda, A., Shimonaka, M., Kinashi, T. Nat. Immunol. 4, 741–748 (2003).

    Article  CAS  Google Scholar 

  7. Bos, J.L., de Rooij, J. & Reedquist, K.A. Nat. Rev. Molec. Cell Biol. 2, 369–377 (2001).

    Article  CAS  Google Scholar 

  8. Boussiotis, V.A., Freeman, G.J., Berezovskaya, A., Barber, D.L. & Nadler, L.M. Science 278, 124–128 (1997).

    Article  CAS  Google Scholar 

  9. Mueller, D.L. & Jenkins, M.K. Curr. Op. Immunol. 7, 375–381 (1995).

    Article  CAS  Google Scholar 

  10. Abraham, R.T. Nat. Immunol. 3, 212–213 (2002).

    Article  CAS  Google Scholar 

  11. Shimonaka, M. et al. J. Cell Biol. 161, 417–427 (2003).

    Article  CAS  Google Scholar 

Download references

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  1. Program in Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, 92037, California, USA

    Robert T Abraham

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  1. Robert T Abraham
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Abraham, R. Rap1 redux. Nat Immunol 4, 725–727 (2003). https://doi.org/10.1038/ni0803-725

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  • DOI: https://doi.org/10.1038/ni0803-725

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