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The CD1b structure: antigen presentation adapts to a high-fat diet

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CD1b protein presents glycolipids of various tail lengths to T cells. The crystal structure of CD1b sheds light on its ability to accommodate these different glycolipids.

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Figure 1: The family of MHC class I–related lipid-binding proteins.

Bob Crimi

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Authors and Affiliations

  1. Department of Microbiology, Immunology, and Molecular Genetics, University of California School of Medicine, Los Angeles, 90095, CA, USA

    Kayvan R. Niazi & Robert L. Modlin

  2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, 10461, NY, USA

    Steven A. Porcelli

  3. Molecular Biology Institute and Division of Dermatology, University of California School of Medicine, Los Angeles, 90095, CA, USA

    Robert L. Modlin

Authors
  1. Kayvan R. Niazi
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  2. Steven A. Porcelli
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  3. Robert L. Modlin
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Niazi, K., Porcelli, S. & Modlin, R. The CD1b structure: antigen presentation adapts to a high-fat diet. Nat Immunol 3, 703–704 (2002). https://doi.org/10.1038/ni0802-703

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