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Affecting the effectors: a kick in the gut?

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After leaving lymphoid tissues, do T cells receive additional signals for survival and differentiation at effector sites? A unique cell population in the intestinal lamina propria may provide such a signal via the costimulatory molecule CD70.

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Figure 1: In the intestine, the initial activation of naive T cells occurs mainly in organized lymphoid tissues such as Peyer's patches (PP), isolated colonic follicles or mesenteric lymph nodes (MLN).

Katie Ris

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Authors and Affiliations

  1. Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Cecilia Johansson & Brian L Kelsall

Authors
  1. Cecilia Johansson
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  2. Brian L Kelsall
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Johansson, C., Kelsall, B. Affecting the effectors: a kick in the gut?. Nat Immunol 6, 644–646 (2005). https://doi.org/10.1038/ni0705-644

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