Toll-like receptors trigger an innate immune response by activating signaling pathways that are dependent on IRAK kinases. According to Kawagoe et al., the least understood IRAK member, IRAK2, is required for the perpetuation of these signals.
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Meylan, E., Tschopp, J. IRAK2 takes its place in TLR signaling. Nat Immunol 9, 581–582 (2008). https://doi.org/10.1038/ni0608-581
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DOI: https://doi.org/10.1038/ni0608-581
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