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Antifungal defense turns 17

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Fungal recognition occurs partially through the C-type lectin dectin-1. New studies show that dectin-mediated immune recognition of Candida albicans induces the differentiation of interleukin 17–producing T helper cells that express chemokine receptors characteristic of mucosal homing.

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Figure 1: Dectins and TLRs induce distinct T helper cell responses.

Kim Caesar

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Authors and Affiliations

  1. Noah W. Palm and Ruslan Medzhitov are with the Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06405, USA. ruslan.medzhitov@yale.edu,

    Noah W Palm & Ruslan Medzhitov

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  1. Noah W Palm
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  2. Ruslan Medzhitov
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The authors declare no competing financial interests.

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Palm, N., Medzhitov, R. Antifungal defense turns 17. Nat Immunol 8, 549–551 (2007). https://doi.org/10.1038/ni0607-549

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