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Opn: key regulator of pDC interferon production

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Plasmacytoid dendritic cells selectively express Toll-like receptors 7 and 9 and respond to virus infection by triggering massive interferon production, a pathway regulated by osteopontin expressed in plasmacytoid dendritic cells.

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Figure 1: In pDCs, herpes simplex virus 1 (HSV-1) and CpG DNA trigger T-bet-mediated induction of Opn expression.

Katie Ris

References

  1. Colonna, M., Trinchieri, G. & Liu, Y.J. Nat. Immunol. 5, 1219–1226 (2004).

    Article  CAS  Google Scholar 

  2. Liu, Y.-J. Annu. Rev. Immunol. 23, 275–306 (2005).

    Article  CAS  Google Scholar 

  3. Kawai, T. & Akira, S. Nat. Immunol. 7, 131–137 (2006).

    Article  CAS  Google Scholar 

  4. Shinohara, M.L. et al. Nat. Immunol. 7, 498–506 (2006).

    Article  CAS  Google Scholar 

  5. Mazzali, M. et al. Q. J. Med. 95, 3–13 (2002).

    Article  CAS  Google Scholar 

  6. Pass, H.I. et al. N. Engl. J. Med. 353, 1564–1573 (2005).

    Article  CAS  Google Scholar 

  7. Gravallese, E.M. J. Clin. Invest. 112, 147–149 (2003).

    Article  CAS  Google Scholar 

  8. Shinohara, M.L. et al. Proc. Natl. Acad. Sci. USA 102, 17101–17106 (2005).

    Article  CAS  Google Scholar 

  9. Ashkar, S. et al. Science 287, 860–864 (2000).

    Article  CAS  Google Scholar 

  10. Zohar, R. et al. J. Cell. Physiol. 184, 118–130 (2000).

    Article  CAS  Google Scholar 

  11. Abel, B., Freigang, S., Bachmann, M.F., Boschert, U. & Kopf, M. J. Immunol. 175, 6006–6013 (2005).

    Article  CAS  Google Scholar 

  12. Chabas, D. et al. Science 294, 1731–1735 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, Texas, USA

    Wei Cao & Yong-Jun Liu

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  1. Wei Cao
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  2. Yong-Jun Liu
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Cao, W., Liu, YJ. Opn: key regulator of pDC interferon production. Nat Immunol 7, 441–443 (2006). https://doi.org/10.1038/ni0506-441

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