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Chemokines as immunotransmitters?

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Chemokines not only act as chemotactic and chemokinetic molecules but also are inducers of integrin-dependent adhesion. Analysis of an immunological synapse now demonstrates an additional function for chemokines as costimulatory molecules.

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Figure 1: The chemokine receptor CCR5 is recruited at a T cell–B cell synapse (1) and this recruitment probably requires chemokine secretion by the APC1.

Katie Ris

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Authors and Affiliations

  1. Institut Cochin, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Paris, 75014, France

    Alain Trautmann

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  1. Alain Trautmann
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Trautmann, A. Chemokines as immunotransmitters?. Nat Immunol 6, 427–428 (2005). https://doi.org/10.1038/ni0505-427

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