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Rolling on N-linked glycans: a new way to present L-selectin binding sites

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Recruitment of lymphocytes to the lymph nodes requires L-selectin-mediated recognition of carbohydrate determinants presented by O-glycans. New work shows that N-glycans 'decorated' with the same determinants also contribute to lymphocyte homing.

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Figure 1: O-glycans and N-glycans 'decorate' CD34, a chief L-selectin ligand component of PNAd.

Katie Ris

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Authors and Affiliations

  1. Ronen Alon is in the Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel.,

    Ronen Alon

  2. Steven Rosen is in the Department of Anatomy and Program in Immunology, University of California, San Francisco, San Francisco, California, 94143-0451, USA.,

    Steven Rosen

Authors
  1. Ronen Alon
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  2. Steven Rosen
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Correspondence to Ronen Alon or Steven Rosen.

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The authors declare no competing financial interests.

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Alon, R., Rosen, S. Rolling on N-linked glycans: a new way to present L-selectin binding sites. Nat Immunol 8, 339–341 (2007). https://doi.org/10.1038/ni0407-339

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