The current paradigm is that reactive oxygen species produced by leukocytes directly kill bacteria. Data in a recent Nature article belie that simplicity.
References
Reeves, E. P. et al. Nature 416, 291–297 (2002).
Dinauer, M. C., Nauseef, W. M. & Newburger, P. E. in The Metabolic and Molecular Basis of Inherited Diseases (eds Scriver, C. R. et al.), Ch. 133 (McGraw-Hill, New York, 2000).
Hampton, M. B., Kettle, A. J. & Winterbourn, C. C. Infect. Immun. 64, 3512–3517 (1996).
Aratani, Y. et al. Infect. Immun. 67, 1828–1836 (1999).
Nanda, A., Curnutte, J. T. & Grinstein, S. J. Clin. Invest. 93, 1770–1775 (1994).
Henderson, L. M., Chappell, J. B. & Jones, O. T. Biochem. J. 246, 325–329 (1987).
Kolset, S. O. & Gallagher, J. T. Biochim. Biophys. Acta 1032, 191–211 (1990).
Rausch, P. G. & Moore, T. G. Blood 46, 913–919 (1975).
Tkalcevic, J., et al. J. Immunity 12, 201–210 (2000).
Donnenberg, M. S. Nature 406 768–774 (2000).
Henderson, L. M. & Meech, R. W. J. Gen. Physiol. 114, 771–786 (1999).
Diebold, B. A. & Bokoch, G. M. Nature Immunol. 2, 211–215 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bokoch, G. Microbial killing: hold the bleach and pass the salt!. Nat Immunol 3, 340–342 (2002). https://doi.org/10.1038/ni0402-340
Issue Date:
DOI: https://doi.org/10.1038/ni0402-340
- Springer Nature America, Inc.
This article is cited by
-
Hydrogen peroxide as second messenger in lymphocyte activation
Nature Immunology (2002)