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Mitochondrial control of the NLRP3 inflammasome

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During the past few decades, the vital and lethal functions of mitochondria have been investigated extensively. Data now demonstrate that these organelles also regulate the innate immune response by modulating inflammasome-mediated generation of proinflammatory cytokines.

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Figure 1: Mitochondrial death and danger signaling.

References

  1. Kroemer, G., Galluzzi, L. & Brenner, C. Physiol. Rev. 87, 99–163 (2007).

    Article  CAS  Google Scholar 

  2. Vandenabeele, P., Galluzzi, L., Vanden Berghe, T. & Kroemer, G. Nat. Rev. Mol. Cell Biol. 11, 700–714 (2010).

    Article  CAS  Google Scholar 

  3. Nakahira, K. et al. Nat. Immunol. 12, 222–230 (2011).

    Article  CAS  Google Scholar 

  4. Zhou, R., Yazdi, A.S., Menu, P. & Tschopp, J. Nature 469, 221–225 (2011).

    Article  CAS  Google Scholar 

  5. Zitvogel, L., Kepp, O. & Kroemer, G. Cell 140, 798–804 (2010).

    Article  CAS  Google Scholar 

  6. Kawai, T. & Akira, S. Int. Immunol. 21, 317–337 (2009).

    Article  CAS  Google Scholar 

  7. Seth, R.B., Sun, L., Ea, C.K. & Chen, Z.J. Cell 122, 669–682 (2005).

    Article  CAS  Google Scholar 

  8. Dostert, C. et al. Science 320, 674–677 (2008).

    Article  CAS  Google Scholar 

  9. Saitoh, T. et al. Nature 456, 264–268 (2008).

    Article  CAS  Google Scholar 

  10. Zhang, Q. et al. Nature 464, 104–107 (2010).

    Article  CAS  Google Scholar 

  11. Galluzzi, L., Kepp, O., Zitvogel, L. & Kroemer, G. Curr. Biol. 20, R106–R108 (2010).

    Article  CAS  Google Scholar 

  12. Travassos, L.H. et al. Nat. Immunol. 11, 55–62 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Oliver Kepp and Lorenzo Galluzzi are with Institut National de la Santé et de la Recherche Médicale, U848, Villejuif, France, Institut Gustave Roussy, Villejuif, France, and Université Paris-Sud, Villejuif, France.,

    Oliver Kepp & Lorenzo Galluzzi

  2. Guido Kroemer is with Institut National de la Santé et de la Recherche Médicale, U84s8, Villejuif, France, Metabolomics Platform, Institut Gustave Roussy, Villejuif, France, Centre de Recherche des Cordeliers, Paris, France, Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France, and Université Paris Descartes, Paris, France.,

    Guido Kroemer

Authors
  1. Oliver Kepp
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  2. Lorenzo Galluzzi
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  3. Guido Kroemer
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Corresponding author

Correspondence to Guido Kroemer.

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The authors declare no competing financial interests.

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Kepp, O., Galluzzi, L. & Kroemer, G. Mitochondrial control of the NLRP3 inflammasome. Nat Immunol 12, 199–200 (2011). https://doi.org/10.1038/ni0311-199

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