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CD8+ thymocyte differentiation: T cell two-step

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A new study demonstrates that commitment to the CD8 lineage in the thymus requires sequential T cell antigen receptor (TCR) and interleukin 7 (IL-7) signaling. The TCR signal first induces IL-7 responsiveness, then recognition of IL-7 induces the nuclear factor Runx3, which specifies the CD8 lineage.

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Figure 1: IL-7 signaling subsequent to TCR signaling is required for CD8SP differentiation but not for CD4SP differentiation.

Katie Vicari

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Authors and Affiliations

  1. Nicholas R.J. Gascoigne is in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Nicholas R J Gascoigne

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  1. Nicholas R J Gascoigne
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Correspondence to Nicholas R J Gascoigne.

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Gascoigne, N. CD8+ thymocyte differentiation: T cell two-step. Nat Immunol 11, 189–190 (2010). https://doi.org/10.1038/ni0310-189

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