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CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIV

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Maternal-infant transmission provides a useful model for the study of immune factors associated with protection against the acquisition of human immunodeficiency virus and has emphasized the importance of CCL3 in protective immunity to this virus.

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Figure 1: CCL3 production by cord blood cells.
Figure 2: Possible influence of CCL3 and CCL3L1 genotype on the development of adaptive immunity to HIV vaccines and restoration of loss of function in people with deficient production through the provision of CCL3 as adjuvant.

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Acknowledgements

We thank the clinical and laboratory staff, students and other researchers who have contributed to work that led to the ideas addressed here. Supported by the National Institute of Child Health and Human Development (42402), the Poliomyelitis Research Foundation of South Africa, the South African AIDS Vaccine Initiative of South Africa and the Wellcome Trust (076352/Z/05/Z to C.T.T.).

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Author notes

  1. Louise Kuhn is with the Gertrude H. Sergievsky Centre, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA.

Authors and Affiliations

  1. Caroline T. Tiemessen is with the AIDS Virus Research Unit, National Institute for Communicable Diseases and University of the Witwatersand, Sandringham 2131, South Africa. carolinet@nicd.ac.za,

    Caroline T Tiemessen & Louise Kuhn

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  1. Caroline T Tiemessen
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  2. Louise Kuhn
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The authors declare no competing financial interests.

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Tiemessen, C., Kuhn, L. CC chemokines and protective immunity: insights gained from mother-to-child transmission of HIV. Nat Immunol 8, 219–222 (2007). https://doi.org/10.1038/ni0307-219

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