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Nef: out and in?

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Lentiviral Nef protein has many functions in the evasion of host immune defenses. Another 'chink' in the host immune 'armor' has now been exposed by Nef's ability to inhibit immunoglobulin class switching.

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Figure 1: Nef exits infected cells, enters B cells and suppresses CSR.

Katie Ris

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Peterlin, B. Nef: out and in?. Nat Immunol 7, 229–230 (2006). https://doi.org/10.1038/ni0306-229

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  • DOI: https://doi.org/10.1038/ni0306-229

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