Skip to main content
SpringerLink
Log in

Defining 'stemness': Notch and Wnt join forces?

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Self-renewal of hematopoietic stem cells allows life-long production of blood cells. Notch signaling is critically involved in this process by maintaining a pool of self-renewing hematopoietic stem cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Notch loss-of-function approaches and effects on HSCs.

K.R.

References

  1. Reya, T., Morrison, S.J., Clarke, M.F. & Weissman, I.L. Nature 414, 105–111 (2001).

    Article  CAS  Google Scholar 

  2. Sauvageau, G., Iscove, N.N. & Humphries, R.K. Oncogene 23, 7223–7232 (2004).

    Article  CAS  Google Scholar 

  3. Duncan, A.W. et al. Nat. Immunol. 6, 314–322 (2005).

    Article  CAS  Google Scholar 

  4. Staal, F.J.T. & Clevers, H.C. Nat. Rev. Immunol. 5, 21–30 (2005).

    Article  CAS  Google Scholar 

  5. Pawliuk, R., Eaves, C. & Humphries, R.K. Blood 88, 2852–2858 (1996).

    CAS  Google Scholar 

  6. Siminovitch, L., McCulloch, E.A. & Till, J.E. J. Cell Physiol. 62, 327–336 (1963).

    Article  CAS  Google Scholar 

  7. Radtke, F., Wilson, A., Mancini, S.J.C. & MacDonald, H.R. Nat. Immunol. 5, 247–253 (2004).

    Article  CAS  Google Scholar 

  8. Wu, L. et al. Nat. Genet. 26, 484–489 (2000).

    Article  CAS  Google Scholar 

  9. Galceran, J., Sustmann, C., Hsu, S.C., Folberth, S., Grosschedl, R. Genes Dev. 18, 2718–2723 (2004).

    Article  CAS  Google Scholar 

  10. Jamieson, C.H. et al. N. Engl. J. Med. 351, 657–667 (2004).

    Article  CAS  Google Scholar 

  11. Yang, L. et al. Blood advance online publication, 30 November 2004 (doi 10.1182/blood-2004-06-2159).

  12. Han, H. et al. Int. Immunol. 14, 637–645 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, 221 84, Sweden

    Sten Eirik W Jacobsen

Authors
  1. Sten Eirik W Jacobsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jacobsen, S. Defining 'stemness': Notch and Wnt join forces?. Nat Immunol 6, 234–236 (2005). https://doi.org/10.1038/ni0305-234

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0305-234

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation