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Dendritic cells giveth and taketh away

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Resting dendritic cells can induce T cell tolerance. This process requires engagement of the costimulatory molecules PD-1 and CTLA-4 on T cells.

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Figure 1: Immune activation and tolerance induced by dendritic cells.

K.R.

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Authors and Affiliations

  1. Department of Pathology, University of California San Francisco, San Francisco, 94143, California, USA

    Abul K Abbas & Arlene H Sharpe

  2. Department of Pathology, Harvard Medical School and Brigham & Women's Hospital, Boston, 02115, Massachusetts, USA

    Abul K Abbas & Arlene H Sharpe

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  1. Abul K Abbas
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  2. Arlene H Sharpe
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Abbas, A., Sharpe, A. Dendritic cells giveth and taketh away. Nat Immunol 6, 227–228 (2005). https://doi.org/10.1038/ni0305-227

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