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NLRP3 has a sweet tooth

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The signaling intermediates that activate inflammasomes are elusive. New data now show that reactive oxygen species causes TXNIP to associate with NLRP3 and activate the inflammasome.

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Figure 1: ROS signal the NLRP3 inflammasome.

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Authors and Affiliations

  1. Beckley K. Davis and Jenny Pan-Yun Ting are in the Department of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Beckley K Davis & Jenny Pan-Yun Ting

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  1. Beckley K Davis
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  2. Jenny Pan-Yun Ting
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Correspondence to Jenny Pan-Yun Ting.

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Davis, B., Ting, JY. NLRP3 has a sweet tooth. Nat Immunol 11, 105–106 (2010). https://doi.org/10.1038/ni0210-105

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