Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators.
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References
Szabo, S.J., Sullivan, B.M., Peng, S.L. & Glimcher, L.H. Annu. Rev. Immunol. 21, 713–758 (2003).
Murphy, K.M. & Reiner, S.L. Nat. Rev. Immunol. 2, 933–944 (2002).
Djuretic et al. Nat. Immunol. 8, 145–153 (2007).
Taniuchi, I. et al. Cell 111, 621–633 (2002).
Yarmus, M. et al. Proc. Natl. Acad. Sci. USA 103, 7384–7389 (2006).
Laslo, P. et al. Cell 126, 755–766 (2006).
Hu, M. et al. Genes Dev. 11, 774–785 (1997).
Medina, K.L. et al. Dev. Cell 7, 607–617 (2004).
Maier, H. et al. Nat. Immunol. 5, 1069–1077 (2004).
Mikkola, I., Heavey, B., Horcher, M. & Busslinger, M. Science 297, 110–113 (2002).
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Singh, H. Shaping a helper T cell identity. Nat Immunol 8, 119–120 (2007). https://doi.org/10.1038/ni0207-119
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DOI: https://doi.org/10.1038/ni0207-119
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