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Toll signaling: the TIReless quest for specificity

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The identification of a third TIR domain adaptor molecule involved in TLR3-mediated interferon-β induction helps explain TLR signaling specificity.

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Figure 1: TLRs use different combinations of TIR domain adaptors to activate cellular responses.

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique UPR9022, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, Strasbourg, 67000, France

    Jean-Luc Imler & Jules A. Hoffmann

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  1. Jean-Luc Imler
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  2. Jules A. Hoffmann
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Imler, JL., Hoffmann, J. Toll signaling: the TIReless quest for specificity. Nat Immunol 4, 105–106 (2003). https://doi.org/10.1038/ni0203-105

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