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Lymphoid organogenesis: getting the green light from RORγt

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Lymphoid tissue inducer (LTi) cells are central to the development of lymphoid organs during embryonic development. Only these cells express the nuclear receptor RORγt, which turns out to be indispensable for LTi cell survival and function.

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Figure 1: Lymph node and Peyer's patch development depends on expression of RORγt by LTi cells.

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Lipp, M., Müller, G. Lymphoid organogenesis: getting the green light from RORγt. Nat Immunol 5, 12–14 (2004). https://doi.org/10.1038/ni0104-12

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