Skip to main content
SpringerLink
Log in

NK cells join the plasticity party

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The cytokine TGF-β allows tumors to evade the immune system by converting conventional natural killer cells into type 1 innate lymphoid cells devoid of cytotoxic function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: TGF-β converts NK cells into iILC1s–ILC1-like cells via non-canonical signaling pathways negatively regulated by SMAD4.

Debbie Maizels/Springer Nature

References

  1. Artis, D. & Spits, H. Nature 517, 293–301 (2015).

    Article  CAS  Google Scholar 

  2. Gury-BenAri, M. et al. Cell 166, 1231–1246 (2016).

    Article  CAS  Google Scholar 

  3. Gao, Y. et al. Nat. Immunol. 18, 1004–1015 (2017).

    Article  CAS  Google Scholar 

  4. Cortez, V.S. et al. Nat. Immunol. 18, 995–1003 (2017).

    Article  CAS  Google Scholar 

  5. Cortez, V.S. et al. Immunity 44, 1127–1139 (2016).

    Article  CAS  Google Scholar 

  6. Denney, L. et al. Immunity 43, 945–958 (2015).

    Article  CAS  Google Scholar 

  7. Ikushima, H. & Miyazono, K. Nat. Rev. Cancer 10, 415–424 (2010).

    Article  CAS  Google Scholar 

  8. Dadi, S. et al. Cell 164, 365–377 (2016).

    Article  CAS  Google Scholar 

  9. Crome, S.Q. et al. Nat. Med. 23, 368–375 (2017).

    Article  CAS  Google Scholar 

  10. Pikovskaya, O. et al. J. Immunol. 196, 1449–1454 (2016).

    Article  CAS  Google Scholar 

  11. Robinette, M.L. et al. Nat. Immunol. 16, 306–317 (2015).

    Article  CAS  Google Scholar 

  12. Simoni, Y. et al. Immunity 46, 148–161 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, Maryland, USA

    Jonathan S Silver & Alison A Humbles

Authors
  1. Jonathan S Silver
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alison A Humbles
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alison A Humbles.

Ethics declarations

Competing interests

J.S.S. and A.A.H. are full-time employees of MedImmune and hold shares in AstraZeneca.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Silver, J., Humbles, A. NK cells join the plasticity party. Nat Immunol 18, 959–960 (2017). https://doi.org/10.1038/ni.3817

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3817

  • Springer Nature America, Inc.

Search

Navigation