Skip to main content
SpringerLink
Log in

Polymorphisms in IFIH1: the good and the bad

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The common polymorphism p.A946T in IFIH1 has been linked to a variety of autoimmune diseases.

Debbie Maizels/Springer Nature

References

  1. Gorman, J.A. et al. Nat. Immunol. 18, 744–752 (2017).

    Article  CAS  Google Scholar 

  2. Smyth, D.J. et al. Nat. Genet. 38, 617–619 (2006).

    Article  CAS  Google Scholar 

  3. Nejentsev, S., Walker, N., Riches, D., Egholm, M. & Todd, J.A. Science 324, 387–389 (2009).

    Article  CAS  Google Scholar 

  4. Dai, X. et al. J. Clin. Invest. 123, 2024–2036 (2013).

    Article  CAS  Google Scholar 

  5. Rice, G.I. et al. Nat. Genet. 46, 503–509 (2014).

    Article  CAS  Google Scholar 

  6. Pestal, K. et al. Immunity 43, 933–944 (2015).

    Article  CAS  Google Scholar 

  7. Liddicoat, B.J. et al. Science 349, 1115–1120 (2015).

    Article  CAS  Google Scholar 

  8. Rice, G.I. et al. Nat. Genet. 44, 1243–1248 (2012).

    Article  CAS  Google Scholar 

  9. Domsgen, E. et al. Sci. Rep. 6, 39378 (2016).

    Article  CAS  Google Scholar 

  10. Yi, G. et al. PLoS One 8, e77846 (2013).

    Article  CAS  Google Scholar 

  11. Crow, Y.J. & Manel, N. Nat. Rev. Immunol. 15, 429–440 (2015).

    Article  CAS  Google Scholar 

  12. Fischer, A. & Rausell, A. Sci. Immunol. 1, eaah5861 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France

    Erika Della Mina & Mathieu P Rodero

  2. Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, Paris, France

    Yanick J Crow

  3. Sorbonne-Paris-Cité, Hôpital Necker Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France

    Yanick J Crow

  4. Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK

    Yanick J Crow

Authors
  1. Erika Della Mina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mathieu P Rodero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yanick J Crow
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yanick J Crow.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Della Mina, E., Rodero, M. & Crow, Y. Polymorphisms in IFIH1: the good and the bad. Nat Immunol 18, 708–709 (2017). https://doi.org/10.1038/ni.3765

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3765

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation