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RNA-binding proteins mind the GAPs

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Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.

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Figure 1: Increased TRAF6 expression reduces the abundance of GAPs via ubiquitination of hnRNP-A1.

References

  1. Sibley, C.R., Blazquez, L. & Ule, J. Nat. Rev. Genet. 17, 407–421 (2016).

    Article  CAS  Google Scholar 

  2. Pellagatti, A. & Boultwood, J. Adv. Biol. Regul. http://dx.doi.org/10.1016/j.jbior.2016.08.001 (2016).

  3. Fang, et al. Nat. Immunol. 18, 236–245 (2017).

  4. Monlish, D.A., Bhatt, S.T. & Schuettpelz, L.G. Front. Immunol. 7, 390 (2016).

    Article  Google Scholar 

  5. Starczynowski, D.T. et al. Nat. Med. 16, 49–58 (2010).

    Article  CAS  Google Scholar 

  6. Jean-Philippe, J., Paz, S. & Caputi, M. Int. J. Mol. Sci. 14, 18999–19024 (2013).

    Article  Google Scholar 

  7. Wang, L., Yang, L., Filippi, M.-D., Williams, D.A. & Zheng, Y. Blood 107, 98–105 (2006).

    Article  CAS  Google Scholar 

  8. Tavanez, J.P., Madl, T., Kooshapur, H., Sattler, M. & Valcárcel, J. Mol. Cell 45, 314–329 (2012).

    Article  CAS  Google Scholar 

  9. Huppertz, I. et al. Methods 65, 274–287 (2014).

    Article  CAS  Google Scholar 

  10. Turner, M., Galloway, A. & Vigorito, E. Nat. Immunol. 15, 484–491 (2014).

    Article  CAS  Google Scholar 

  11. Tenekeci, U. et al. Mol. Cell 62, 943–957 (2016).

    Article  CAS  Google Scholar 

  12. Lee, S.C.-W. & Abdel-Wahab, O. Nat. Med. 22, 976–986 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Martin Turner is with the Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK.,

    Martin Turner

  2. and the Department of Biochemistry, Elisa Monzón-Casanova is with the Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge, UK, University of Cambridge, Cambridge, UK.,

    Elisa Monzón-Casanova

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  1. Martin Turner
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  2. Elisa Monzón-Casanova
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Correspondence to Martin Turner.

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Turner, M., Monzón-Casanova, E. RNA-binding proteins mind the GAPs. Nat Immunol 18, 146–148 (2017). https://doi.org/10.1038/ni.3662

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